CAS 2407527-16-4 | MK-0616; Enlicitide Chloride

Product Description

CAS 2407527-16-4 (MK-0616, Enlicitide chloride) is an orally bioavailable macrocyclic peptide derivative designed as a potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9). The compound selectively binds to PCSK9, preventing its interaction with low-density lipoprotein receptors (LDLR) and preserving cellular LDL clearance mechanisms in cardiovascular research settings.

Primary Applications

• Pharmaceutical Development: Serves as an active active pharmaceutical candidate for research into oral lipid-lowering therapies and hypercholesterolemia management.
• Cardiovascular Research: Applied in preclinical models to evaluate receptor recycling pathways, plasma cholesterol regulation, and atherosclerotic plaque progression.
• Peptide Chemistry Studies: Utilized in drug discovery to explore structural optimization and oral absorption profiles of macrocyclic peptide molecules.

Storage & Handling

Store under dry, sealed conditions at sub-zero temperatures (-20°C). Protect from moisture, atmospheric air, and light to maintain compound integrity and prevent peptide bond degradation.

Synonyms