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Canbi Pharma Technology is a subsidiary of Chongqing Kalan Pharmaceutical Co., Ltd.(Also known as CONIER CHEM AND PHARMA LIMITED). It was founded in the first economic and technological development zone in Southwest China. It is a young company focusing on the fields of organic chemistry and biological engineering. The company specializes in the development, production, and sales of chemicals, new materials, pharmaceutical intermediates, and APIs.

 

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Our History

It is a young company focusing on the fields of organic chemistry and biological engineering. The company specializes in the development, production, and sales of chemicals, new materials, pharmaceutical intermediates, and APIs.

 

Our service

We divide inquiries into two categories: service-focused and project-focused. We view some inquiries as an opportunity to provide long-term supply chain services to customers, while we manage other inquiries with rigorous project management.

Our Information

In the past 15 years, we have provided products to customers in over 30 countries and won the trust of many famous international companies.

 

Our Group

Our group mainly includes three companies. Shanghai Canbi Pharmaceutical Technology Co., Ltd. is located in the economic center of China, Shanghai.

 

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What Is Butylated Hydroxytoluene

 

 

Butylated hydroxytoluene (BHT), also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its antioxidant properties. It plays an important role in maintaining quality and performance of raw materials and products by preventing their deterioration due to the reaction with oxygen in the air (oxidation). Since BHT is heat stable, it is useful to prevent oxidation of certain raw materials during manufacturing processes that involve heating.

 

 
Advantages of Butylated Hydroxytoluene
 
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Antioxidant Properties: Butylated hydroxytoluene acts as a potent antioxidant, inhibiting the oxidation of oils, fats, and other substances. Its ability to scavenge free radicals helps in delaying the degradation of food products, extending their shelf life.

02/

Stability Enhancement: By preventing oxidative degradation, butylated hydroxytoluene improves the stability of products, including food, cosmetics, pharmaceuticals, and industrial materials. It helps extend the shelf life and maintain the quality of various products.

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Flavor and Fragrance Preservation: Butylated hydroxytoluene helps preserve the flavors and fragrances of food and personal care products, ensuring their quality over time. This improves overall food safety for consumers.

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Protection Against Environmental Stressors: Butylated hydroxytoluene has been found to offer protective effects against environmental stressors in biological systems. It can protect cells from oxidative stress induced by pollutants, radiation, or toxins.

 

Is Butylated Hydroxytoluene Safe?

 

A lot of research has gone into determining how safe BHT is, and if it leads to any significant adverse effects. A comprehensive report on the safety of BHT published in the International Journal of Toxicology concluded that BHT demonstrates "no significant irritation, sensitization, or photosensitization" in those who use this ingredient, according to currently available research.
Since BHT is used at low concentrations in beauty products, it’s considered safe to use in cosmetic formulations. The FDA has approved BHT as a food additive in limited quantities in some foods as well.

 

What is the difference between BHT and BHA?
 

Both BHT and BHA are synthetic antioxidants commonly used in the food and cosmetics industry to preserve fats and oils and to prevent products from spoiling. However, there are some significant differences between the two:

Chemical structure
BHT and BHA are different chemical compounds. BHT is a derivative of toluene (a colorless liquid found naturally in oil). BHA is a man-made antioxidant that is almost completely synthetic.

Solubility
BHT is soluble in fats and oils, whereas BHA is soluble in fats, oils, and some other substances (such as propylene glycol, petroleum ether, chloroform, and 50% alcohol). For this reason, BHT is primarily used in cosmetics and foods that contain fats and oils. BHA, on the other hand, is used in a wider range of cosmetics and foods, including baked goods, meats, and beverages.

Safety
Both BHT and BHA are considered safe to use by the FDA in small quantities. However, BHA has carcinogenic potential, whereas BHT does not.

 

Dosing
 

The appropriate dose of BHT depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for BHT. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Application of Butylated Hydroxytoluene

Food preservative: Butylated hydroxytoluene is commonly used as an antioxidant food preservative to prevent lipid oxidation and rancidity in foods, fats, and oils.
Cosmetics and personal care: Butylated hydroxytoluene is added to cosmetics, lotions, and personal care products as an antioxidant to prevent spoilage and product degradation.
Fuel stabilizer: Butylated hydroxytoluene is used as a fuel stabilizer to prevent the oxidation and degradation of gasoline, diesel, and other fuels during storage.
Rubber and plastics: Butylated hydroxytoluene is incorporated into rubber and plastic products to improve their oxidative stability and extend their useful life.
Animal feed: Butylated hydroxytoluene is added to animal feeds as a preservative to prevent lipid oxidation and spoilage.
Pharmaceuticals: Butylated hydroxytoluene has applications in the pharmaceutical industry as an antioxidant to stabilize drug formulations.
Lubricants and greases: Butylated hydroxytoluene is used as an antioxidant additive in lubricants, greases, and other industrial fluids.

Flame retardant

Butylated hydroxytoluene has some flame retardant properties and can be used in certain applications to provide fire resistance.

Emulsion stabilizer

Butylated hydroxytoluene can act as an emulsion stabilizer in various liquid-liquid and solid-liquid systems.

Research applications

Butylated hydroxytoluene is used in research laboratories as a model compound for studying antioxidant mechanisms and oxidation processes.

 

BHT (Butylated Hydroxytoluene) Synthesis Method

 

 

A method of synthesizing BHT, comprising: p-cresol and ionic liquid acid are continuously mixed in a pipeline mixer according to a certain proportion, are injected into a gas-liquid reactor and react with isobutene introduced into the gas-liquid reactor under a certain condition, after full reaction, reaction liquid flows out of the reactor and enters a phase separation tank to separate a catalyst from a product, an upper BHT product is extracted and sent to a rectifying tower to be refined, and a lower ionic liquid acid is boosted by a circulating pump and then is mixed with injected raw material p-cresol in the pipeline mixer and then enters the reactor to react with the isobutene, so that continuous synthesis and separation of the BHT are realized.

 

Crystallization Method of High-Purity Antioxidant Butylated Hydroxytoluene (BHT)

 

The invention discloses a crystallization method of high-purity antioxidant BHT (butylated hydroxytoluene). The method comprises the following steps: adding paracresol and isobutanol as raw materials, and adding concentrated sulfuric acid as a catalyst; conducting an alkylation reaction by controlling the temperature and time, wherein the reaction comprises two stages, in the first stage, the alkylation reaction is conducted in vacuum and a constant-temperature mode is adopted for crystallization, and in the second stage, the alkylation reaction is conducted under micro-positive pressure and a direct freezing mode is adopted for crystallization; finally reacting in the presence of the catalyst to obtain an alkylated mixed solution based on antioxidant BHT. According to the method, the yield of the alkylation reaction, the output quantity and the finished product content are increased, and crystal scales or crystal scars formed on the wall of a kettle are reduced; a product is uniform in crystal particles, high in purity, good in glossiness and long in quality guarantee period.

 

How to Dissolve BHT (Butylated Hydroxytoluene) in Distilled Water?
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Dissolving BHT (Butylated Hydroxytoluene) in distilled water is a relatively simple process because BHT is a lipophilic (fat-soluble) compound that can be easily dissolved in organic solvents. While BHT is not very soluble in water, you can use a co-solvent like ethanol or propylene glycol to help it dissolve more readily in distilled water.

Prepare a Mixing Container

Use a clean and dry mixing container. The size of the container depends on the quantity of BHT you need to dissolve.
Measure BHT

Measure the desired amount of BHT powder you want to dissolve. Ensure that the container is dry to prevent any moisture from affecting the process.
Add Co-solvent

To help BHT dissolve more easily in water, add a co-solvent like ethanol or propylene glycol. The choice of co-solvent may depend on the specific application, but ethanol is commonly used. The ratio of co-solvent to BHT can vary, but you may start with roughly equal parts by weight. For example, if you have 1 gram of BHT, you can add 1 gram of ethanol.
Mix Thoroughly

Stir the mixture vigorously to dissolve the BHT in the co-solvent. You can use a stirring rod or, if available, a magnetic stirrer to facilitate the mixing process. Continue stirring until you achieve a homogeneous solution.
Add Distilled Water

Gradually add distilled water to the mixture while stirring continuously. Continue to stir until you reach the desired concentration. The final concentration of BHT in water can vary depending on your specific application and requirements.
Store the Solution

Once you've achieved the desired BHT concentration in the water, store the solution in a clean, labelled container. Seal it tightly to prevent moisture absorption or evaporation.

Keep in mind that BHT is used as an antioxidant in various applications, so the concentration and specific formulation may vary depending on the intended use. Ensure that you follow any guidelines or recommendations for your specific application when preparing the BHT solution. Additionally, safety precautions should be taken when handling BHT, including wearing appropriate personal protective equipment and working in a well-ventilated area.

 

What Is Indoline

 

 

Indoline is a type of organic compound that is aromatic and heterocyclic, having the chemical formula C8H9N. Its structure is composed of two rings, a six-membered benzene ring and a five-membered ring containing nitrogen, which are fused together to form a bicyclic structure. By oxidation/dehydrogenation it can be converted to indole. Indoline can be produced from the reaction of indole, zinc and 85% phosphoric acid. It was used to make Indocaine.

 

What Does Indoline do for the Body?
 

Support for Detoxification: Indolines may boost the activity of enzymes involved in detoxification pathways in the liver to support the transformation and elimination of certain substances and hormones like estrogen from the body.

Anti-Inflammatory Properties: Indolines are known to be antioxidants that help neutralize harmful free radicals in the body that can cause damage to cells. In this way, Indolines may help manage oxidative stress and support overall health. These antioxidant properties contribute to the potential anti-inflammatory effects of Indolines.

Hormonal Balance: By promoting the conversion of estrogen to its less active forms, Indolines may help maintain hormonal balance, supporting reproductive health.

Cardioprotective Effects: Indolines may offer cardioprotective effects, including modulation of vascular function, inflammation, and oxidative stress, which could be valuable for supporting cardiovascular health.

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Development And Application Of Indolines In Pharmaceuticals

 

Indolines or dihydroindoles play a key role in drug discovery, and many drugs containing indoline cores have been reported recent years. We focus on indoline compounds in development, synthesis and use as anticancer drugs, antibacterial drugs etc. in recent years. Through the analysis of the indolines’ interaction with proteins and highlighting the advantages of its properties in drug design, this review aims to provide a toolbox for readers to design and discover new drugs.

 

The indoline structure exists in a huge number of natural products, but drugs with indoline have only been formally studied in recent years. With the deepening of research, drugs containing indoline have played important roles in more disease treatment aspects, such as anti‐tumor, anti‐bacterial, anti‐inflammatory and have been used as analgesics, to treat cardiovascular diseases and so on.

 

The synthesis and pharmacological activity of indoline derivatives is summarized in this review in order to support the addition of the indoline component to the toolbox of medicinal chemists. This review focuses on the advantages of indoline compounds in development and synthesis of and for the use as anticancer drugs, antibacterial drugs, to treat cardiovascular diseases and as anti‐inflammatory and analgesic drugs.

 

Indoline structures are commonly found in natural and synthetic compounds with medicinal value and are now beginning to be exploited as the basic backbone of various drugs. As research continues, dihydroindoles and their derivatives will play a greater role in the medical field.

 

Approach to the Synthesis of Indoline Derivatives from Diaryliodonium Salts

 

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An effective method of constructing the indoline moiety via intramolecular nucleophilic ring closure of a diaryliodonium salt is described. Diacetoxyiodoarene compounds (1a–1e) were converted into intermediate Koser’s reagent and coupled with arylstannanes (7–10) to form diaryliodonium salts (11a–14e). Indoline compounds with different N-protecting groups, 15, 16, 17, and 18, were synthesized in higher yields by treating salts (11a–14e) with Cs2CO3 and TEMPO. Regardless of the electronic environment of five para-substituted iodoarenes and the natures of four N-protected arylstannane groups, the conversion proceeded well to afford corresponding indolines in yields of 72–84 and 70–84%, respectively.

 

What is the reactivity of Indoline with other compounds?
 

Indoline is a bicyclic organic compound characterized by a five-membered nitrogen-containing ring fused to a six-membered aromatic ring. Its reactivity is influenced by the nitrogen atom, which can participate in various chemical reactions. Indoline typically undergoes electrophilic aromatic substitution reactions due to the presence of the aromatic ring, making it susceptible to halogenation, nitration, and sulfonation. Additionally, the nitrogen atom can serve as a nucleophile, allowing for reactions with electrophiles, such as alkyl halides and acyl chlorides, leading to the formation of more complex derivatives.

 

Moreover, indoline can participate in cyclization reactions and can be utilized as a building block for synthesizing more intricate organic compounds. Its reactivity can be modulated through substitution at various positions on the aromatic ring or through functionalization of the nitrogen atom, which opens pathways for the development of pharmaceuticals and dyes. Overall, the unique structure of indoline enables it to engage in a diverse array of chemical transformations, making it a valuable compound in organic synthesis.

 

How to Test for Indoline?
 

Thin Layer Chromatography
Prepare a TLC plate and spot a small amount of the indoline sample alongside a pure standard. Develop the plate in an appropriate solvent, then visualize the spots. A single spot corresponding to the standard indicates higher purity.

 

High-Performance Liquid Chromatography
Use HPLC to separate and quantify indoline and any potential impurities. The area under the curve for indoline can be compared to the total area to calculate the purity.

 

Nuclear Magnetic Resonance Spectroscopy
Conduct NMR analysis to identify the structure and purity of indoline. The ratio of the integrals of indoline's peaks to any impurities can indicate purity levels.

 

Infrared Spectroscopy
Compare the IR spectrum of your indoline sample to that of a pure sample. Differences in characteristic peaks can indicate impurities.

 

 
FAQ

 

Q: What is a safe amount of butylated hydroxytoluene?

A: BHT is also considered safe for a combined use of mouthwash at a concentration of 0.001%, toothpaste at a concentration of 0.1% and other leave-on and rinse-off products at the concentration of 0.8%.

Q: Can butylated hydroxytoluene be absorbed through the skin?

A: BHT does penetrate the skin, but the relatively low amount absorbed remains primarily in the skin. Oral studies demonstrate that BHT is metabolized. The major metabolites appear as the carboxylic acid of BHT and its glucuronide in urine.

Q: What does butylated hydroxytoluene do to your body?

A: Butylated hydroxytoluene is an antioxidant. It may damage the protective outer layer of viral cells. This may keep the viruses from multiplying and/or doing more damage. BHT is an antioxidant.

Q: Is butylated hydroxytoluene a hormone disruptor?

A: BHT is accused of being an endocrine disruptor and of having toxic effects on the liver, kidneys and lungs at extreme doses, by ingestion. BHT is also suspected of having a potential for bioaccumulation in aquatic species.

Q: Is butylated hydroxytoluene in lotion bad?

A: The amount of BHT uses in cosmetic products is typically 0.0002%-0.5%. Such low amounts do not pose a risk to skin (indeed, the safety assessment found BHT was non-irritating) nor does it penetrate skin far enough to be absorbed into the bloodstream.

Q: Is butylated hydroxytoluene hard on the liver?

A: The results show that BHT has adverse effects in the liver. BHT is metabolized by the cytochrome P450 system in the liver and may be converted to prooxidative compounds during this process. Adipose tissue lacks the cytochrome P450 system.

Q: Why is butylated hydroxytoluene used in cosmetics?

A: It is a common synthetic compound that is used as a preservative in cosmetic formulations to stabilize the formulation and prevent its oxidation. It maintains the properties of a formulation like color, odor, and texture, which may change upon exposure to air.

Q: Is butylated hydroxytoluene still in use?

A: Butylated hydroxytoluene, or BHT, is a substance used in many industrial, commercial and consumer applications. It can be used as a preservative in foods and food packaging materials. It can also be found in a variety of products available to consumers, including: cosmetics.

Q: The Difference Between BHA and BHT?

A: BHA is an oil-soluble waxy solid with the E number E320, and BHT is an oil-soluble white powder with the E number E321. Fatty or oily foods treated with BHA and BHT taste better for longer, due to their chain-breaking antioxidants that quench free radicals.

Q: What is the difference between indole and indoline?

A: Indoline is an aromatic heterocyclic organic compound with the chemical formulation C8H9N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing ring. The compound is based on the indole structure, but the 2-3 bond is saturated.

Q: What are the uses of indoline?

A: Indolines are core structures found in many natural products and pharmaceuticals. They have been extensively used in the design of anticancer drugs, particularly HDAC and Kinase inhibitors, and have shown promising potential in inhibiting various targets involved in cancer progression.

Q: What is the toxicity of indoline?

A: The electrochemical potential is reduced when indoline passes through the cytoplasmic membrane. Thus, high indolin concentrations are toxic to bacterial cell growth, apart from the fact that indoline functions as a signal.

As one of the leading intermediate manufacturers and suppliers in China, we warmly welcome you to buy high-grade intermediate in stock here from our company. All our products are with high quality and competitive price.

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