CAS 2260696-63-5 | PP405,JXL-069
Name: 2- Propenoic acid, 3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-cyano-, (2E)-
CAS number: 2260696-63-5
Molecular formula: C20H11F6N3O2
Molecular weight: 439.31
EINECS number: 100-001-2
MDL No.：
PP405 (JXL-069) | CAS 2260696-63-5
PP405 (also known as JXL-069) is a potent, selective small-molecule inhibitor targeting the mitochondrial pyruvate carrier (MPC). It is extensively utilized in metabolic reprogramming research, cellular signaling assays, hair follicle stem cell activation studies, and targeted oncology models.
Specifications & Identifiers
| CAS Number | 2260696-63-5 |
| English Name | (2E)-3-[1-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-cyano-2-propenoic acid |
| Molecular Formula | C20H11F6N3O2 |
| Molecular Weight | 439.31 g/mol |
| Appearance | Off-white to light yellow solid powder |
| Purity | ≥ 98% (HPLC) |
| Storage Conditions | Store at -20 °C, keep desiccated and protected from direct sunlight |
Primary Applications
- Mitochondrial pyruvate carrier (MPC) inhibition assays.
- Preclinical hair follicle stem cell (HFSC) activation research.
- Cellular metabolic flux and glycolytic reprogramming studies.
- Oncology drug discovery and target validation experiments.
Performance Features
- High nanomolar potency and exceptional target selectivity.
- Demonstrated ability to stimulate cellular lactate production.
- Favorable structural stability for in vitro biochemical assays.
- High purity suitable for quantitative laboratory evaluations.
Synonyms / Alternative Names
PP405 • JXL-069 • JXL069 • PP-405 • Suvomipic • CAS 2260696-63-5 • (E)-2-Cyano-3-(1-(3,5-bis(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acrylic acid • (2E)-3-[1-[[3,5-双(三氟甲基)苯基]甲基]-1H-吡咯并[2,3-B]吡啶-3-基]-2-氰基-2-丙烯酸
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