CAS 946002-48-8 | SAG 21k

SAG 21k (CAS 946002-48-8)

Potent Hedgehog Signaling Pathway Activator & Biochemical Reagent

Product Overview

SAG 21k (Smoothened Agonist 21k) is a highly potent, small-molecule activator that targets the Smoothened (Smo) receptor within the Hedgehog (Hh) signaling pathway. Known for its exceptional specificity, this compound serves as an essential tool in developmental biology, oncology, and stem cell research, facilitating a deeper understanding of cellular differentiation and tissue regeneration mechanisms.

Distinctive Features

• High Functional Potency: Exhibits robust activation of the Hh pathway at nanomolar concentrations, providing reproducible and highly reliable experimental results.
• Target Specificity: Interacts directly with the heptahelical bundle of Smoothened, minimizing off-target interactions in complex biological assays.
• Premium Purity Profile: Manufactured under strict analytical controls to guarantee high chemical and biological purity, preventing interference from trace impurities.
• Reliable Solubilization: Shows excellent solubility in dimethyl sulfoxide (DMSO) and other standard organic vehicles for seamless preparation of stock solutions.

Target Applications

Synonyms / Alternative Names

Hedgehog agonist 1; Smoothened Agonist 21k; 3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide; Compound 21k; Hh agonist 1.