CAS 148152-66-3 | (±)-Epibatidine

Product Description

(±)-Epibatidine (CAS 148152-66-3) is a chlorinated alkaloid originally isolated from the skin of the Ecuadoran poison frog, Epipedobates tricolor. Structurally categorized as an exo-7-azabicyclo[2.2.1]heptane derivative, this compound functions as a potent agonist at both nicotinic acetylcholine receptors (nAChRs) and ganglionic receptors. It is synthesized primarily for neuropharmacological research and ligand-binding assays.

Technical Specification

Research Applications

• Nicotinic Receptor Characterization: Utilized in laboratory research to study the subtypes of central and peripheral nicotinic acetylcholine receptors.
• Analgesic Pathway Studies: Applied in vivo and in vitro models to investigate non-opioid antinociceptive mechanisms and pathways.
• Structure-Activity Relationship (SAR): Serves as a reference scaffold for designing and synthesizing selective nAChR ligands with modified toxicity profiles.
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Handling and Storage

Store the solid compound at -20°C in a tightly sealed container, protected from light and moisture. This compound exhibits high biological potency; handle strictly in accordance with standard laboratory hazardous chemical safety protocols. Utilize a fume hood and wear appropriate personal protective equipment (PPE), including gloves and safety goggles, to avoid accidental exposure.

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