CAS 736992-21-5 | Elamipretide

Specification:

Appearance	White to Off-White powder
Purity	98%+

 

Application:

     Elamipretide (also known as SS-31, Bendavia, MTP-131) is a synthetic mitochondria-targeted tetrapeptide with the sequence: D-Arg-Dmt-Lys-Phe-NH₂. It acts as a potent cardiolipin peroxidase inhibitor and antioxidant, selectively localizing to the inner mitochondrial membrane to stabilize structure, reduce ROS, and enhance ATP production.

1.1 Clinical & Medical Applications

Cardiovascular Diseases

Heart failure (Phase II/III clinical trials)

Myocardial infarction & ischemia-reperfusion injury

Diabetic cardiomyopathy

Barth syndrome (FDA breakthrough therapy designation)

Neurological Disorders

Alzheimer's & Parkinson's disease (neuroprotection)

Stroke & traumatic brain injury

LPS-induced cognitive/memory impairment

Metabolic & Renal Diseases

Acute kidney injury (AKI) & chronic renal disease

Diabetic nephropathy & retinopathy

Islet cell transplantation (reduces apoptosis)

Ophthalmology

Dry eye disease, retinitis pigmentosa

Rare Mitochondrial Diseases

 

 

Synonyms:

RX-31
SS-31
MTP-131

(S)-6-Amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide
Bendavia

SS-31(Elamipretide MTP-131)
Elamipretide

 

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