179324-69-7 Bortezomib

Properties

Appearance White solid
Melting point:122-124°C
Density 1.214
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.
pka9.66±0.43
Stability:Hygroscopic and Moisture Sensitive

 

Application:

    Bortezomib, also known as: MG-341; Impurities in bortezomib. This product can be used in combination with melphalan and prednisone (MP regimen) for the treatment of previously untreated multiple myeloma patients who are not suitable for high-dose chemotherapy and bone marrow suppression; Or monotherapy is used for the treatment of multiple myeloma patients who have received at least one or more treatments but have relapsed; This product can be used for the treatment of recurrent or refractory mantle cell lymphoma patients who have received at least one treatment before using this product. The safety and efficacy data for this indication comes from a single arm phase II clinical study conducted abroad on mantle cell lymphoma that recurred after previous treatment.

 

Synonyms:

Bortezomib

179324-69-7

Bortezomib accord

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid

Peptide boronate

N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-((1S)-1-Benzyl-2-(((1R)-1-(dihydroxyboranyl)-3-methylbutyl)amino)-2-oxoethyl)pyrazinecarboxamide

radiciol

Pyz-Phe-boroLeu

(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid

BORTEZOMIB HYDRATE [JAN]

[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid

Boronic acid, ((1R)-3-methyl-1-(((2S)-1-oxo-3-phenyl-2-((pyrazinylcarbonyl)amino)propyl)amino)butyl)-

N-((1S)-1-benzyl-2-(((1R)-1-(dihydroxyboranyl)-3-methylbutyl)amino)2-oxoethylpyrazinecarboxamide

Velcade

DPBA

[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid

bortezomibum

Bortezomib hydrate

Bortezomib,Velcade

LPD-341

N-((1R)-1-(DIHYDROXYBORYL)-3-methylbutyl)-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

((1R)-3-Methyl-1-(((2S)-3-phenyl-2-((pyrazinylcarbonyl)amino)propanoyl)amino)butyl)boronic acid

[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid;Radiciol

N-((1R)-1-(dihydroxyboranyl)-3-methylbutyl)-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

Velcade (Millenium)

1610526-91-4

PS-341 [Bortezomib]

Bortezomib

Bortezomib - Bio-X trade mark

GTPL6391

 

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