CAS 27767-85-7 | RO4-1539

Receptor Pharmacology & CNS Studies

• Characterizes subtype selectivity across mu- (μ), kappa- (κ), and delta- (δ) opioid receptors.
• Probes ligand-induced conformational changes and G-protein coupling mechanisms in neural membranes.
• Serves as a specialized tool for mapping central pain pathways and antinociceptive signaling cascades.

Structure-Activity Relationship (SAR) Exploration

• Evaluates the influence of heterocyclic N-alkyl modifications on morphinan core binding affinities.
• Provides benchmark data for computational docking and 3D quantitative structure-activity relationship (3D-QSAR) modeling.
• Aids in designing novel analgesic candidates with modified side-effect profiles.

Medicinal Chemistry & Analytical Standards

• Functions as a reference compound in competitive radioligand binding and displacement assays.
• Utilized in organic synthesis research for developing functionalized morphinan derivatives.
• Acts as a high-purity analytical standard for chromatographic quantification and metabolic profiling.

Handling & Storage Context

Strictly intended for laboratory research, CRO drug discovery pipelines, and academic biochemical investigations. Store as a solid in tightly closed containers at 2–8°C or -20°C in a dry, dark place protected from light and moisture.