CAS 268545-87-5 | NBI-34041

Product Overview

NBI-34041 (CAS 268545-87-5) is a selective, non-peptide antagonist of the corticotropin-releasing factor type 1 (CRF1) receptor. It is synthesized for research in neurobiology and endocrinology to investigate stress-response pathways, anxiety-related neurocircuitry, and hypothalamic-pituitary-adrenal (HPA) axis regulation.

Primary Applications & Characteristics

• Neuroscience & Pharmacological Research: Serves as a reference small-molecule ligand to block CRF signaling and study receptor binding kinetics in central nervous system models.
• Endocrine System Studies: Applied in preclinical evaluations examining ACTH and cortisol regulation under physiological and induced stress conditions.
• Medicinal Chemistry Intermediate: Acts as a specialized chemical intermediate for designing novel heterocyclic compounds and modulating central receptor activity.
• Targeted Selectivity: Demonstrates high affinity for CRF1 receptor sites over related receptor subtypes in receptor binding assays.

Synonyms & Commercial Names