CAS 147127-20-6 | Tenofovir

Properties

Appearance white to beige powder
Melting point:276-280°C
Boiling point:616.1±65.0 °C 
Density 1.79±0.1 g/cm3 
storage temp. -20°C
 

Application:

In the process of AIDS virus (HIV -1) replication, nucleotide analogue reverse transcriptase inhibitors can block HIV replication. The combination of this drug and other antiretroviral drugs can improve the therapeutic effect and be used to treat AIDS caused by HIV-1 infection.

Item	Details
Main Clinical Applications	- Treatment of HIV‑1 infection in adults and children - Treatment of chronic hepatitis B (HBV) infection - Used in combination antiretroviral therapy (ART) - Used in pre-exposure prophylaxis (PrEP) for HIV prevention
Related Forms	Tenofovir Disoproxil Fumarate (TDF), Tenofovir Alafenamide (TAF)

 

 

Key Synthetic Intermediates

Intermediate Name	CAS	Role
(R)-9-(2-Hydroxypropyl)adenine	14047-28-0	adenine nucleoside intermediate
Diethyl (p-toluenesulfonyloxymethyl)phosphonate	144470-76-4	Phosphonate side‑chain building block
Ethyl dichlorophosphate	1498-51-7	Phosphorylation reagent
Adenine	73-24-5	Starting material for purine ring
(S)-Propylene carbonate	16606-55-6	Chiral precursor for the hydroxypropyl side chain

 

 

 

Synonyms:

Tenofovir

147127-20-6

(R)-9-(2-Phosphonomethoxypropyl)adenine

(R)-PMPA

tenofovir (anhydrous)

anhydrous tenofovir

Tenofovir anhydrous

Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-

(R)-9-(Phosphonomethoxypropyl)adenine

(R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid

(((1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonic acid

Phosphonic acid, ((2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)-, (R)-

 

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