335-10-4 | Perfluoroisobutyric Acid
English name: Perfluoroisobutyric acid
CAS number: 335-10-4
Molecular formula: C4HF7O2
Molecular weight: 214.04
EINECS number:
MDL No.：MFCD01695470
| Item | Details |
|---|---|
| Physical State | Colorless, odorless liquid (20°C) |
| Boiling Point | 117-118°C |
| Melting Point | Approx. -40°C |
| Density | 1.65 g/cm³ (25°C) |
| Refractive Index | 1.29 (20°C) |
| Acidity (pKa) | Approx. 0.5 (strong acid) |
| Purity | Typically 97% or higher (industrial grade) |
| Properties | High chemical/thermal stability; strong acidity; low surface tension; good solubility in polar and non-polar solvents |
| Applications |
1. Analytical Chemistry: Ion-pair reagent for reversed-phase HPLC (peptide/protein separation, LC-MS); mobile phase modifier to enhance separation selectivity; derivatization reagent for GC-MS. 2. Pharmaceutical & Agrochemical Intermediates: Building block for fluorinated APIs (e.g., anti-infectives, anti-cancer drugs) and pesticides (insecticides, herbicides); synthesis of fluorinated heterocycles. 3. Materials Science: Surfactant/additive for fluoropolymer synthesis (improves thermal stability, weather resistance); surface treatment agent for metals/glass (enhances wettability and corrosion resistance); additive in electroplating (refines coating morphology). 4. Other: Catalyst in organic synthesis; electrolyte additive in lithium-ion batteries (improves performance and safety). |
| Safety & Handling | Corrosive (causes severe skin/eye burns); irritating to respiratory tract; store in cool, dry, well-ventilated area; use PPE (gloves, goggles, face shield) |
Route of Synthesis:
Synonyms:
Perfluoroisobutyric acid
Heptafluoroisobutyric acid
2,3,3,3-tetrafluoro-2-(trifluoromethyl)propanoic acid
335-10-4
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