Canbi Pharma Tech Limited
19436-52-3 | N-Acetyl-D-alanine

19436-52-3 | N-Acetyl-D-alanine

Product name: AC-D-ALA-OH
CAS number: 19436-52-3
Molecular formula: C5H9NO3
Molecular weight: 131.13
EINECS number: 243-066-8
MDL No.:MFCD00063133

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Description

Properties:

Appearance: White to off-white solid

Melting point: 125 °C
Boiling point: 369.7±25.0 °C
Density: 1.170

 

Application:

Applications

Pharmaceutical Intermediate

 1. Peptide Drug Synthesis: Chiral building block for manufacturing D-amino acid-containing peptides (e.g., antimicrobial peptides, opioid receptor agonists, and protease inhibitors). The acetyl group protects the amino terminal during peptide coupling, preventing side reactions.

2. Antibiotic Production: Used in the synthesis of semi-synthetic β-lactam antibiotics (e.g., modified penicillins and cephalosporins) to improve antibacterial spectrum and stability against β-lactamases.

3. CNS Drug R&D: Applied in the preparation of D-amino acid derivatives targeting NMDA receptors, which are potential treatments for schizophrenia, Alzheimer's disease, and ischemic stroke.

 

Food & Feed Industry

1. Flavor Enhancer: As a chiral additive to improve the taste and aroma of processed foods (e.g., beverages, dairy products, and savory snacks); enhances umami flavor without increasing sodium content.

2. Feed Supplement: Added to animal feed to promote growth and improve nutrient utilization; the D-configuration is resistant to enzymatic degradation in the gut, extending its bioavailability.

 

Biomedical Research

1. Chiral Resolution Reagent: Used to separate racemic amino acid mixtures via HPLC or capillary electrophoresis, due to its specific chiral recognition ability.

2. Enzyme Substrate: Serves as a substrate for studying the specificity of aminoacylases, proteases, and other enzymes involved in amino acid metabolism.

 

Material Science

1. Chiral Polymer Monomer: Polymerized with diols or diacids to prepare optically active polyamides, which are used in chiral stationary phases for chromatography, nonlinear optical materials, and biodegradable plastics.

Packaging Specifications (Lab & Industrial Grade)

Lab/Research Grade Packaging

- Sealed amber glass vials with Teflon-lined screw caps, specifications: 5 g, 25 g,  100 g; vacuum-sealed to prevent moisture absorption and racemization; labeled with purity (≥99.0%), optical purity (ee ≥99.5%), batch number, and storage conditions

 

.✅ Industrial/Production Grade Packaging

1. 25 kg/50 kg Fiber Drums: With double polyethylene (PE) inner liners for moisture-proof and leak-proof protection; drum labels include CAS number, product name, net weight, hazard warnings (slightly irritant to skin/eyes), and transportation marks.

2. 1000 kg Bulk Bags (FIBC): For large-volume shipments; equipped with lifting loops and PE liners; suitable for automated production line integration.

3. Customized Packaging: 1 kg/5 kg aluminum foil vacuum bags for small-batch commercial sales; compliant with ICH Q7 GMP standards for pharmaceutical applications.

 

 

Synthesis  Route:

product-336-67

 

Synonyms:

Ac-D-Ala-OH
AC-D-ALA-OH
Ac-D-Ala-Oh
AC-D-ALANINE
N-Ac-D-Ala-OH
ACETYL-D-ALANINE

19436-52-3
D-Alanine, N-acetyl-
N-ALPHA-ACETYL-D-ALANINE
N-acetyl-D-alanine  
(2R)-2-acetamidopropanoic acid

 

For more product information, please contact us!!!

 

 

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