937263-43-9 Tucatinib

Properties

Appearance White to yellow crystalline solid
Density 1.41±0.1 g/cm3
storage temp. Store at -20°C
solubility DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
pka6.61±0.70

 

Application:

    Tucatinib is a targeted drug used to block HER2 activity, helping to slow down the growth and spread of cancer cells. It is mainly used for the treatment of HER2 positive metastatic breast cancer patients. In addition, Tukatiniatrastuzumab can treat chemotherapy resistant HER2 positive metastatic colorectal cancer. This drug has shown excellent performance in clinical trials, with significant efficacy and high safety.

    Tucatinib, as an oral targeting drug, is widely used in the treatment of HER2 positive breast cancer. Breast cancer is a common malignant tumor, and HER2 positive breast cancer is one of its subtypes. This article will provide a detailed introduction to the pharmacological effects, indications, usage and dosage, as well as possible side effects of tocatinib.

 

Synonyms:

Tucatinib

Irbinitinib

937263-43-9

N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine

Irbinitinib; ARRY-380; ONT-380

4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)-

MK-7119

N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine

N6-(4,5-dihydro-4,4-dmethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-A)pyridin-7-Yloxy)phenyl)-4,6-quinazolinediamine

4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-

6-N-(4,4-dimethyl-5H-1,3-oxazol-2-yl)-4-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine

tucatinibum

N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine

ONT-380;Tucatinib

N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine

C26H24N8O2

Tucatinib (Irbinitinib, ONT-380)

Tucatinib (Irbinitinib,ARRY-380)?

ARRY-380; 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-; N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;

N6-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-N4-(3-methyl-4-{[1,2,4]triazolo[1,5-a]pyridin-7-yloxy}phenyl)quinazoline-4,6-diamine

 

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