1197953-54-0 Brigatinib

Properties
Melting point:>203°C (dec.)
Boiling point:781.8±70.0 °C
Density 1.31±0.1 g/cm3
storage temp. -20°C
solubility Soluble in DMSO (1 mg/ml with warming)
pka8.14±0.42
Appearance White to off-white solid

 

Application:

    Brigatinib inhibits the growth and spread of cancer cells by blocking the function of proteasomes.

    Proteasome is one of the important protein degradation systems in cells, involved in regulating cellular life activities. Brigatinib can interfere with the metabolism and proliferation of cancer cells by specifically binding to and inhibiting proteasome enzymes, promoting cancer cells to enter an apoptotic state.

    Brigatinib is mainly administered via intravenous injection and is commonly used for the treatment of multiple myeloma, especially in advanced and refractory cases. It is also used to treat certain other types of leukemia and non Hodgkin lymphoma.

 

Synonyms:

Brigatinib

1197953-54-0

AP 26113

(2-((5-chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine

2,4-Pyrimidinediamine, 5-chloro-N4-(2-(dimethylphosphinyl)phenyl)-N2-(2-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)-

(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethyl-,delta5-phosphanone

5-Chloro-N~4~-[2-(Dimethylphosphoryl)phenyl]-N~2~-{2-Methoxy-4-[4-(4-Methylpiperazin-1-Yl)piperidin-1-Yl]phenyl}pyrimidine-2,4-Diamine

5-Chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine

brigatinibum

Alunbrig 

5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine; AP 26113

Brigatinib; AP26113

Brigatinib (AP-26113)

(2-((5-CHLORO-2-((2-METHOXY-4-(4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL)PHENYL)AMINO)PYRIMIDIN-4-YL)AMINO)PHENYL)DIMETHYL-,.DELTA.5-PHOSPHANONE

(2-((5-Chloro-2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)anilino)pyrimidin-4-yl)amino)phenyl)dimethyl-lambda5-phosphanone

2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine ox ide

5-Chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine

 

 

 

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