CAS 50-76-0 | Actinomycin D
Product Name:Actinomycin D
CAS:50-76-0
MF:C62H86N12O16
MW:1255.42
EINECS:200-063-6
MDL No.:MFCD00005033
Specification:
| Appearance |
Bright red crystalline powder
|
|
Identification
|
Ultraviolet absorption
Ratio:A 240 /A 445 between 1.30 to1.50
|
|
Solubility
|
Soluble in acetone, ethyl acetate
|
|
Specific rotation
|
﹣292° ～ ﹣317°
|
|
Total impurities (HPLC)
|
≤5.0%
|
|
Loss on drying
|
≤5%
|
|
Purity ( HPLC)
|
≥95%
|
Application:
Actinomycin D is an interferon inducer used clinically as an anti-tumor drug.
| Category | Application Details | Route/Use | Indications/Use Cases |
|---|---|---|---|
| Clinical Oncology | Antineoplastic chemotherapy (IV infusion); radiosensitizer | Intravenous (IV); combination with radiotherapy | Wilms' tumor, rhabdomyosarcoma, Ewing's sarcoma, gestational trophoblastic neoplasia, testicular cancer, ovarian cancer; VAC regimen (vincristine + cyclophosphamide + actinomycin D) |
| Molecular Biology Research | Transcription inhibition model; gene expression regulation; DNA damage repair studies | In vitro cell culture; biochemical assays | Blocks DNA-dependent RNA polymerase; studies on RNA synthesis, MDR mechanisms, DNA repair pathways (NER, HR) |
| Cell Biology & Assays | Apoptosis induction; cell viability staining (via 7-AAD derivative); cell culture selection agent | Flow cytometry; microscopy; cell culture | 7-AAD for dead/live cell discrimination; apoptosis assays; selection in yeast/rRNA studies |
Intermediates
| Intermediate Name | Abbreviation | Role in Actinomycin D Formation |
|---|---|---|
| 4-Methyl-3-hydroxyanthranilic acid | 4-MHA | Core chromophore (actinocin) building block; essential starter unit |
| 3-Hydroxy-4-methylkynurenine | 3-HMK | Metabolic intermediate in 4-MHA biosynthesis |
| Actinomycin Monolactone | - | Cyclization intermediate; penultimate precursor |
| D-Valine | D-Val | Amino acid residue in pentapeptide lactone rings |
| L-Threonine | L-Thr | Amino acid residue in pentapeptide lactone rings |
| Sarcosine (N-Methylglycine) | Sar | Modified amino acid in peptide rings |
Synonyms:
actinomycin D
50-76-0
Meractinomycin
Cosmegen
Dactinomycinum
Cosmegen Lyovac
Lyovac-Cosmegen
Chounghwamycin B
ActD
Actinomycin X1
Dilactone actinomycin D acid
| Properties |
Safety Information |
Statements |
|
Melting point:251-253 °C Boiling point:848°C (rough estimate) Density 1.0757 (rough estimate) refractive index 1.5700 (estimate) Flash point:87℃ |
Symbol(GHS) GHS06,GHS08 Signal word Danger |
Hazard statements H300-H350-H360FD Precautionary statements P201-P202-P264-P270-P280-P301+P310 Hazard Codes T+ Risk Statements 28-61-40-45-26/27/28 Safety Statements 53-36/37/39-45-1-36/37-28-22 RIDADR UN 3462 6.1/PG 2 |
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