191732-72-6 Lenalidomide

Properties

Appearance White solid
Melting point:265-268 °C
Boiling point:614.0±55.0 °C
Density 1.460±0.06 g/cm3
storage temp. 2-8°C
solubility Soluble in DMSO (up to 30 mg/ml)
pka10.75±0.40
 

Application:

    Lenalidomide is an analog of thalidomide, which has immunomodulatory, anti angiogenic, and anti-tumor effects. The cellular activity of lenalidomide is mediated by its target protein cereblon (a component of the Cullin ring E3 ubiquitin ligase complex). In vitro experiments, substrate proteins (including Aiolos, Ikaros, and CK1 α) are degraded by targeted ubiquitination in the presence of drugs, leading to direct cytotoxic and immunomodulatory effects. Lenalidomide has inhibitory effects on proliferation and promotes apoptosis in certain hematopoietic system tumor cells (including multiple myeloma, mantle cell lymphoma, myelodysplastic syndrome with (5q) deficiency, follicular lymphoma, and marginal zone lymphoma) in vitro. Lenalidomide can delay tumor growth in certain non clinical hematological tumor models (including multiple myeloma) in vivo.

 

Synonyms:

Lenalidomide

191732-72-6

3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

CC-5013

2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

Lenadoamide

Lenalidomida

Revlimid

(3S)-3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline

3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione

3-(4-Amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione

lenalidomidum

Lenalidomide

443912-14-9

Lenalidomide (Standard)

 

 

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