CAS 109889-09-0 | Granisteron

Properties

Appearance White to off-white Powder
Boiling point:532.0±40.0 °C
Density 1.33±0.1 g/cm3
storage temp. Inert atmosphere,Room Temperature
solubility 25℃: DMSO
pka12.34±0.20

 

Application:

Granisteron is an antiemetic drug mainly used to prevent and treat nausea and vomiting caused by chemotherapy and radiotherapy.

Item	Details
Product Name	Granisetron (HCl salt commonly used clinically)
CAS	109889-09-0
Pharmacological Class	Selective 5‑HT₃ receptor antagonist
Clinical Applications	- Prevention & treatment of chemotherapy‑induced nausea & vomiting (CINV)- Prevention & treatment of radiation‑induced nausea & vomiting (RINV)- Prevention & treatment of postoperative nausea & vomiting (PONV)- Off‑label: management of nausea in carcinoid syndrome, functional dyspepsia

 

Key Synthetic Intermediates

Intermediate Name	CAS	Role in Granisetron Synthesis
1‑Methylpiperazine	109‑01‑3	Forms the piperazine moiety; main amine coupling partner
Indazole‑3‑carboxylic acid	4498‑67‑7	Indazole ring precursor; main aromatic fragment
N‑(1‑Methylpiperazin‑4‑yl)‑1H‑indazole‑3‑carboxamide	-	Direct penultimate intermediate; amide coupling product
1‑Methyl‑3‑nitroguanidine	4245‑76‑5	Guanidine fragment building block; used in indazole/piperazine derivatization
4‑Chloro‑N‑methylpiperidine	5058‑43‑5	Piperidine ring precursor; alkylation intermediate

 

 

Synonyms:

granisetron

109889-09-0

Granisetronum

exo-Granisetron

1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide

Granisetronum [INN-Latin]

1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide

1-Methyl-N-[(1r,5s)-9-Methyl-9-Azabicyclo[3.3.1]nonan-3-Yl]indazole-3-Carboxamide

1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo-

124998-65-8

9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv.

1364914-39-5

1-Methyl-N-(9-methyl-endo-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide

 

 

 

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