1802220-02-5 Repotrectinib

Properties

Appearance White to off-white crystalline solid
Density 1.46±0.1 g/cm3
storage temp. Store at -20°C
form A crystalline solid
pka10.79±0.60
 

Application:

    Repotrectinib, It is an anti-cancer drug used to treat non-small cell lung cancer. Repotrectinib is an inhibitor of oncogene tyrosine protein kinase ROS1 (ROS1) and tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, and TRKC.

 

Synonyms:

Repotrectinib

1802220-02-5

Ropotrectinib

repotrectinibum

(3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one

TRX-0005

1,15-Etheno-1H-pyrazolo(4,3-F)(1,4,8,10)benzoxatriazacyclotridecin-4(5H)-one, 11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-

(13E,14E,3R,6S)-45-fluoro-3,6-dimethyl-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphan-9-one

(1Z)-6-Fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentaazatetracyclo(13.5.2.04,9.018,22)docosa-1,4,6,8,15,19,21-heptaen-14-one

1,15-Etheno-1H-pyrazolo(4,3-f)(1,4,8,10)benzoxatriazacyclotridecin-4(5H)-one, 11-fluoro-2,6,7,13-tetrahydro-7,13-dimethyl-, (14Z)-

example 93 (US20170334929A1)

(7S,13R)-11-Fluoro-7,13-Dimethyl-6,7,13,14-Tetrahydro-1,15-Ethenopyrazolo[4,3-F][1,4,8,10]Benzoxatriazacyclotridecin-4(5H)-One

 

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