120202-66-6 Clopidogrel Bisulfate

Properties

Appearance white solid
Melting point:174-176°C
storage temp. 2-8°C
solubility DMSO: ~26 mg/mL
optical activity[α]/D +54 to +70°, c = 0.5 in methanol

 

Application:

    Clopidogrel Bisulfate is a platelet aggregation inhibitor primarily used for the prevention and treatment of circulatory disorders in the heart, brain, and other arteries caused by high platelet aggregation. It is applicable to patients with recent stroke, myocardial infarction and confirmed peripheral artery disease, and can reduce the occurrence of atherosclerosis events, such as myocardial infarction, stroke and vascular death

Category	Details
Applications	1. Acute Coronary Syndrome  2. Percutaneous Coronary Intervention  3. Ischemic Stroke/Transient Ischemic Attack  4. Peripheral Artery Disease (PAD): Reduces major adverse cardiovascular events (MACE) in patients with symptomatic PAD (e.g., intermittent claudication). 5. Secondary Prevention Post-Myocardial Infarction 6. Off-label Uses: Prevention of thrombotic events in atrial fibrillation (when oral anticoagulants are contraindicated); combined with aspirin in some cerebrovascular disease settings (per physician assessment).
KSM Intermediates (Chemical Name, CAS No., Role)	1. DL-o-Chlorophenylglycine (CAS 21160-80-5): Starting material; undergoes esterification and chiral resolution to form the chiral building block. 2. (S)-(+)-2-Chlorophenylglycine Methyl Ester (CAS 141109-15-1): Critical chiral intermediate; formed via optical resolution of DL-o-chlorophenylglycine methyl ester; enables asymmetric synthesis of clopidogrel. 3. 2-(Thiophen-2-yl)ethyl 4-Methylbenzenesulfonate (CAS 56761-71-4): Activated side-chain intermediate; condenses with (S)-2-chlorophenylglycine methyl ester to form the key amine intermediate. 4. (S)-Methyl 2-(2-Chlorophenyl)-2-(2-(Thiophen-2-yl)ethylamino)acetate (CAS 141109-16-2): Condensation product; undergoes cyclization to form the dihydrothienopyridine core structure. 5. (S)-Clopidogrel Free Base (CAS 120202-65-5): Precursor to the bisulfate salt; reacts with sulfuric acid to yield the final API (Clopidogrel Bisulphate).

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Synonyms:

Clopidogrel bisulfate

120202-66-6

Clopidogrel hydrogen sulfate

Clopidogrel bisulphate

Clopidogrel hemisulfate

clopidogrel hydrogen sulphate

(S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate

Clopidogrel zentiva

Clopidogrel ratiopharm

Clopidogrel (hydrogen sulfate)

Clopidogrel (as bisulfate)

S-(+)-Clopidogrel Hydrogen Sulfate

144077-07-6

120202-66-6 (sulfate)

Methyl alphaS-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4H)-acetate sulfate (1:1)

Clopidogrel hydrogensulfate

Plavix 

DUOCOVER COMPONENT CLOPIDOGREL BISULFATE

Clopidogrel sulphate

Methyl (+)-(S)-alpha-(o-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4H)-acetate, sulfate (1:1)

methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate;sulfuric acid

sulfuric acid methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate

Thieno[3,2-c]pyridine-5(4H)-acetic acid,a-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (aS)-, sulfate (1:1)

(S)-(+)-Clopidogrel Sulfate

methyl (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate

methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate sulfate

Clopidogrel Bisulfate 

 

 

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