849217-68-1 Cabozantinib

Properties

Appearance White powder
Melting point:212-215°C
Boiling point:758.1±60.0 °C
Density 1.396
storage temp. -20°C
solubility Soluble in DMSO
pka13.86±0.70

 

Application:

    Cabozantinib (XL184) is a multi-target tyrosine kinase inhibitor (TKI) that can inhibit the expression of multiple key factors such as VEGFR1, VEGFR2, VEGFR3, MET, AXL, RET, KIT, which play important roles in the survival, metastasis, and angiogenesis of tumor cells.
    The uniqueness of cabozantinib lies in its ability to not only inhibit VEGFR, but also specifically inhibit the MET pathway. The MET pathway is closely related to cell proliferation, differentiation, cytoskeleton rearrangement, and cell invasion. By inhibiting MET, cabozantinib can have therapeutic effects on drug-resistant tumors, and its inhibitory effect on the MET pathway gives it a "dual anti-cancer" ability.

    In addition, cabozantinib can inhibit the AXL gene, thereby blocking angiogenesis and directly promoting tumor cell apoptosis. The multiple inhibitory mechanisms of VEGFR, MET, and AXL enable cabozantinib to induce tumor resistance more slowly compared to traditional vascular endothelial growth factor receptor inhibitors, thereby demonstrating more durable therapeutic effects in treatment.

 

Synonyms:

Cabozantinib

849217-68-1

XL184

Cometriq

XL-184 free base

N'-[4-[(6,7-DIMETHOXY-4-QUINOLINYL)OXY]PHENYL]-N-(4-FLUOROPHENYL)-1,1-CYCLOPROPANEDICARBOXAMIDE

1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Cabozantinib 

Cabometyx 

Cometriq 

n-(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

1,1-CYCLOPROPANEDICARBOXAMIDE, N'-(4-((6,7-DIMETHOXY-4-QUINOLINYL)OXY)PHENYL)-N-(4-FLUOROPHENYL)-

1,1-CYCLOPROPANEDICARBOXAMIDE, N-(4-((6,7-DIMETHOXY-4-QUINOLINYL)OXY)PHENYL)-N'-(4-FLUOROPHENYL)-

N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

cabozantinibum

Cabozantinib; N'-?[4-?[(6,?7-?Dimethoxy-?4-?quinolinyl)?oxy]?phenyl]?-?N-?(4-?fluorophenyl)?-1,?1-cyclopropanedicarbox?amide; N'-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide; BMS 907351; N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Cabozantinib (Standard)

Cabozantinib (free base)

 

 

 

 

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