118292-40-3 Tazarotene

Properties

Appearance white to very faintly yellow powder
Melting point:95-98°C
Boiling point:499.8±45.0 °C
Density 1.22±0.1 g/cm3
storage temp. 2-8°C
solubility DMSO: >15mg/mL
pka0.04±0.29

 

Application:

    Tazarotine is an organic compound mainly used as an anti keratotic agent for the treatment of psoriasis and acne, as well as for keratotic disorders, follicular and sebaceous gland diseases, and pre cancerous skin lesions.

Market Application

1. Plaque Psoriasis: Applied to normalize abnormal keratinocyte differentiation, reduce scales and inflammation, often used in combination with corticosteroids for better efficacy. 2. Acne Vulgaris: Used for treating mild to moderate facial acne, improving comedones and inflammatory lesions, and also has a certain effect on post-acne hyperpigmentation. 3. Photoaging: The 0.1% cream is used to improve fine lines, uneven skin tone and age spots caused by sun damage. 4. Other: It can also be used for treating ichthyosis and other keratosis disorders in some cases.

 

Aspect	Details for Tazarotene (Tazarotene)
KMS Raw Material	4,4-Dimethyl-6-ethynyl-thiochroman and Ethyl 6-chloronicotinoate are commonly used-2-8.
Synthetic Route	Reaction Type: Palladium-catalyzed Sonogashira-type coupling-1-7. Feature: No cuprous iodide used, reducing heavy metal waste-1. Process: Palladium catalyst, triphenylphosphine, and an acid-binding agent are added to a solvent, followed by nitrogen purging. Then, 4,4-dimethyl-6-ethynyl-thiochroman and ethyl 6-chloronicotinoate are added to react-1. Advantages: Shorter reaction time, lower temperature, easier catalyst recovery, higher yield and purity-1.

 

Synonyms:

tazarotene

118292-40-3

Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate

tazarotenum

3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester

ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate

ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate

ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate

ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinate

C21H21NO2S

6-(4,4-Dimethyl-thiochroman-6-ylethynyl)-nicotinic acid ethyl ester

Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate;6-(4,4-dimethyl-thiochroman-6-ylethynyl)-nicotinic acid ethyl ester

CAS-118292-40-3

1246815-76-8

Acnitaz

ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)-ethynyl)nicotinate

ethyl 6-((4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl)nicotinate

 

 

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