Canbi Pharma Tech Limited

Entecavir Intermediate

Feb 14, 2024

Step 1:
3-Cyclopenten-1-ol, 2- [(phenylmethod) metal] -, (1R trans) Step 2:
(1S, 2R, 3S, 5R) -2- (benzyloxymethyl) -6-oxabicyclo [3.1.0] hexan-3-ol Step 3:
Step 4:
(1S, 2S, 3S, 5S) -5- (2-amino-6- (benzyloxy) -9H purin-9-yl) -3- (benzyloxy) -2- (benzyloxy) cyclopentanol Step 5:
(2R, 3S, 5S) -3- (benzyloxy) -5- (6- (benzyloxy) -2- ((4-methoxyphenyl) diphenylmethylamine) -9H purin-9-yl) -2- (benzyloxymethyl) cyclopentanol Step 6:
(2R, 3S, 5S) -3- (benzyloxy) -5- (6- (benzyloxy) -2- (4-methoxyphenyl)
Diphenylmethylamino) -9H purin-9-yl) -2- (benzoyloxymethyl) cyclopentanone Step 7:
6- (benzyloxy) -9- ((1S, 3R, 4S) -4- (benzyloxy) -3- (benzyloxy) -2
-Methylenecyclopentyl) - N - (4-methoxyphenyl) diphenylmethyl) -9H purin-2-amine Step 8:
Intermediate of 6- (benzyloxy) -9- ((1S, 3R, 4S) -4- (benzyloxy) -3- (benzyloxy) -2- methylenecyclopentyl) -9H purin-2-amine gadolinium diamine monohydrate aziridipine

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