438056-69-0 4-(4-aminophenyl)morpholin-3-one

Application:

4- (4-aminophenyl) -3-methylpyrrolidone is an intermediate of rivaroxaban, a raw material used in adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE). It is an important intermediate of rivaroxaban.

Downstream Application Field	Specific Products	Product Description
Pharmaceutical Synthesis	Pharmaceutical intermediates (e.g., kinase inhibitors, anti-cancer drugs, anti-inflammatory agents), API precursors	4-(4-Aminophenyl)morpholin-3-one acts as a key heterocyclic building block in pharmaceutical synthesis. Its unique structure (fused morpholin-3-one ring + para-aminophenyl group) enables diverse reactions, including nucleophilic substitution, coupling reactions (e.g., Suzuki coupling, amide condensation), and cyclization. It is widely used in developing kinase inhibitors (targeting cancer, autoimmune diseases) and anti-inflammatory drugs, as the morpholinone ring enhances water solubility and biological compatibility, while the amino group (-NH₂) facilitates precise structural modification of APIs to improve target binding affinity and metabolic stability.
Fine Chemicals	Functional heterocyclic derivatives (e.g., amides, ureas, substituted morpholinones), specialty chemical intermediates	It serves as a precursor for synthesizing fine chemical derivatives. Through chemical modifications (e.g., acylation, alkylation, sulfonylation), it can be converted into substituted morpholinone compounds with tailored properties. These derivatives are applied in corrosion inhibitors, dye intermediates, and polymer modifiers, leveraging their structural versatility and reactivity to enhance product performance (e.g., stability, selectivity).
Drug Discovery & R&D	Compound libraries, lead compound optimization reagents, structure-activity relationship (SAR) research tools	High-purity grades are used in pharmaceutical R&D laboratories and academic institutions. They are employed to construct heterocyclic compound libraries for high-throughput screening (HTS), optimize structure-activity relationships (SAR) of lead compounds, and develop novel drug candidates targeting therapeutic areas such as oncology, neurology, and immunology. The compound's unique morpholinone-aminophenyl scaffold makes it a valuable tool for exploring new drug targets.
Biomedical Research	Biological probes, enzyme inhibitors, receptor modulators	In biomedical research, it is used to synthesize biological probes and tool compounds (e.g., selective enzyme inhibitors, GPCR modulators). These tools help study protein-ligand interactions, signal transduction pathways, and disease mechanisms (e.g., cancer cell proliferation, inflammatory responses), providing critical insights for preclinical drug development and basic life science research.
Material Science	Organic electronic materials (e.g., OLED intermediates, conductive polymers), functional coatings	It serves as a monomer or modifier for synthesizing organic electronic materials. The morpholinone ring's polar structure and amino group's electron-donating property enable tuning of electronic properties (e.g., charge transport, luminescence) in OLED materials and conductive polymers. It is also used in functional coatings to improve adhesion, corrosion resistance, and biocompatibility for industrial equipment and biomedical devices.

 

Synonyms:

4-(4-aminophenyl)morpholin-3-one

438056-69-0

4-(4-aminophenyl)-3-Morpholinone

3-Morpholinone, 4-(4-aminophenyl)-

N-(4-Aminophenyl)-3-morpholinone

4-(3-Oxo-4-morpholinyl)aniline; 4-(4-Aminophenyl)-3-morpholinone; 4-(4-Aminophenyl)morpholin-3-one

4-(4-Amino-phenyl)-morpholin-3-one

 

Properties

Appearance: White to Light Brown solid Melting point:171.0 to 175.0 °C Boiling point:502.3±45.0 °C Density 1.268

 

 

Hot Tags: 438056-69-0 4-(4-aminophenyl)morpholin-3-one, China 438056-69-0 4-(4-aminophenyl)morpholin-3-one manufacturers, suppliers, Benzyl chloride, Sodium xylenesulfonate, diclofenac sodium, 4 Chloro 7H pyrrolo 2 3 d pyrimidine, Chlorophosphonazo III, L-carnitine