CAS 2833703-74-3 | LOXO-435
Name: LOXO-435
CAS number: 2833703-74-3
Molecular formula: C23H22ClFN8O2
Molecular weight: 496.93
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Description
LOXO-435
CAS: 2833703-74-3 • Target: FGFR3 • Class: Small Molecule Inhibitor
LOXO-435 is a isoform-selective, next-generation small-molecule inhibitor targeting fibroblast growth factor receptor 3 (FGFR3). Designed with high selectivity to spare other FGFR isoforms, it is utilized in targeted oncology research for FGFR3-altered solid tumors.
Product Information
- Appearance: Solid powder
- Solubility: Soluble in DMSO
- Storage Conditions: -20 °C, dry and protected from light
- Purity Grade: ≥98% (HPLC) / Research Grade
Research Applications
- FGFR3 Inhibition: Selective biochemical and cellular assays evaluating FGFR3 signaling pathways
- Oncology Studies: Preclinical models of urothelial carcinoma and FGFR3-mutated or fused solid tumors
- Resistance Profiling: Investigation of overcoming gatekeeper and secondary FGFR mutations
Synonyms
LOXO-435 LOXO 435 FGFR3 Inhibitor LOXO-435 Selective FGFR3 Inhibitor
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