CAS 1225208-94-5 | Cefiderocol

Product introduction:

      Cefopidil is a new type of injectable iron carrier cephalosporin that breaks through the defense line of resistant bacteria through the "Trojan horse" mechanism. It is a drug used to treat severe infections caused by carbapenem resistant gram-negative bacteria.

Appearance: White to off white solid

Purity: 95%+

 

 

Application:

Approved indications (FDA/EU/Japan):
    Complex urinary tract infections (cUTI) (including pyelonephritis): Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Enterobacter cloacae.
    Hospital acquired pneumonia/ventilator-associated pneumonia (HAP/VAP): Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacteriaceae.

 

 

Intermediates of Cefiderocol:

7-Aminocephalosporanic acid (7-ACA, CAS 957-68-6)
(Z) 2- (2-aminothiazol-4-yl) -2- [(2-carboxyisopropoxy) imino] acetic acid
2-Aminothiazole-4-carboxylic acid, Tevaleric acid, hydroxylamine derivatives
2-Chloro-3,4-dihydroxybenzoic acid (catechol ring)
1- (2-aminoethyl) pyrrolidine (pyrrolidinethylamine)
Methoxybenzyl chloride (PMB Cl, hydroxyl protected)
2-Chloro-3,4-dimethoxybenzaldehyde (starting material)

 

 

Synonyms:

Fostemsavir

S-649266

1225208-94-5

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((1-(2-(2-chloro-3,4-dihydroxybenzamido)ethyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

2H8]-Cefiderocol

(6R, 7R) -7- [(2Z) -2- (2-amino-1,3-thiazol-4-yl) -2- {[(2-carboxypropan-2-yl) oxy] imino} acetamido] -3- ({1- [2- (2-chloro-3,4-dihydroxybenzamide) ethyl] pyrrolidin-1-ium-1-yl} methyl) -8-oxo-5-thio-1-azabicyclo [4.2.0] oct-2-en-2-carboxylate

2H6]-Cefiderocol

C30H34ClN7O10S2

 

 

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