124750-99-8 | Losartan Potassium

Properties

Appearance Off-white powder or crystals
Melting point:263-265°C
storage temp. Inert atmosphere,Room Temperature
solubility Freely soluble in water and in methanol, slightly soluble in acetonitrile.
Water Solubility H2O: 2mg/mL, clear

 

Application:

     Losartan Potassium is an angiotensin II receptor antagonist (AT1) primarily used for the treatment of primary hypertension. Losartan potassium reduces blood pressure by binding to angiotensin II receptors and blocking their effects. It belongs to the class of angiotensin receptor antagonists (ARBs), and compared to angiotensin converting enzyme inhibitors (ACEIs), losartan potassium typically has better tolerance and fewer side effects.

table:

Category	Details
Applications	1. Hypertension : selective AT1 receptor blockade reduces vasoconstriction/aldosterone release, lowering blood pressure (mono/combination therapy). 2. Left Ventricular Hypertrophy (LVH) in Hypertensives: Slows LVH progression; reduces stroke risk vs. other antihypertensives (LIFE trial data). 3. Type 2 Diabetic Nephropathy: Reduces albuminuria and slows renal function decline (eGFR preservation) in hypertensive diabetic patients. 4. Heart Failure (NYHA II–IV): Used with ACEIs/β-blockers/diuretics; improves symptoms (dyspnea, fatigue) and reduces hospitalization (Val-HeFT trial).
KSM Synthetic Intermediates (Chemical Name, CAS No., Role)	1. 2-Butyl-4-chloro-5-formylimidazole (CAS 103770-08-7): imidazole aldehyde; undergoes N-alkylation with biphenyl benzyl bromide for API backbone. 2. 4'-Bromomethyl-2-cyanobiphenyl (CAS 114772-53-1): Biphenyl alkylating agent; introduces the biphenyl-tetrazole precursor via N-alkylation of imidazole aldehyde. 3. 5-(4'-Bromomethylbiphenyl-2-yl)-1-trityl-1H-tetrazole (CAS 114798-37-7): Trityl-protected tetrazole; prevents tetrazole ring degradation during imidazole coupling. 4. Losartan Free Base (CAS 114798-26-4): Precursor to potassium salt; converted by KOH/K2CO3 for solubility/stability enhancement. 5. 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde (CAS 114798-36-6): Oxidation intermediate/impurity; formed by aldehyde oxidation (used for quality control)

 

Synonyms:

LOSARTAN POTASSIUM

124750-99-8

ERYTHROPOIETIN

Cozaar

losartan potassium salt

Losacar

Losartan monopotassium salt

2-Butyl-4-chloro-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)imidazole-5-methanol, monopotassium salt

HYZAAR COMPONENT LOSARTAN POTASSIUM

MK-954

2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5-methanol potassium

124750-99-8 (Ka+)

1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, monopotassium salt

losartanpotassium

2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt

Potassium, Losartan

Losartan potassium

 

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