33018-91-6 Heptanedioic Acid Monoethyl Ester

Ethyl Hydrogen Pimelate 

1, Product basic information
Physical and chemical properties
Appearance: Colorless to pale yellow transparent liquid at room temperature, colorless at high purity, with a slight light odor unique to ester compounds, and no irritating odors
Melting point: -10 ℃ -8 ℃. 
Boiling point: 150 ℃ -152 ℃ (1.33 kPa vacuum condition), 280 ℃ -282 ℃ (atmospheric pressure). It is not easily decomposed during vacuum distillation and is the preferred process for industrial purification, which can effectively remove impurities
 

2, Product Features
(1) Synergistic reactivity of bifunctional groups
The free carboxyl group (- COOH) in the molecule can undergo typical carboxylic acid reactions such as esterification, amidation, and acyl chloride. The ester group (- COOCH ₂ CH3) can undergo ester characteristic reactions such as hydrolysis, alcoholysis, and ammonolysis. The bifunctional group can participate in the reaction independently or synergistically, and can selectively synthesize derivatives of various structures (such as binary esters, amide esters, acyl chloride esters, etc.), providing a flexible pathway for fine chemical synthesis with high reaction selectivity and few by-products, reducing the difficulty of subsequent separation and purification. ​
(2) Good system compatibility and adaptability
Heptanedioic Acid Monoethyl Ester has good compatibility with various polymer materials (such as polyamide, polyurethane, epoxy resin, acrylic resin) and active intermediates (such as pharmaceutical molecules, pesticide active ingredients), and does not damage the stability of the system, nor does it produce precipitation, delamination or discoloration after addition; It can adapt to organic phase reactions and water organic mixed phase reactions (requiring a small amount of emulsifier), and can be integrated into most production systems without the need for special solvents. It is suitable for production processes in various fields such as medicine, pesticides, coatings, etc. ​
(3) Low toxicity and environmental friendliness
(4) Stable storage and transportation performance
Not easily volatile or decomposed at room temperature, does not require low-temperature refrigeration or special inert gas protection, only requires regular sealed, cool, and dark storage; During transportation, it can withstand slight vibrations and temperature fluctuations (-20 ℃ -40 ℃), and is not easily deteriorated due to changes in external conditions, greatly reducing storage and cross-border transportation costs. It is suitable for long-distance overseas transportation needs.

3, Product Usage and Application Fields
Hydrogen ethyl heptanoate, with its dual functional group activity and good compatibility, is used in overseas fields such as pharmaceuticals, pesticides, fine chemicals, and polymer materials. It is an intermediate product for buyers and distributors in related industries. The specific uses and application areas are as follows:
(1) Medical field
   1. Intermediate of antibacterial and anti-inflammatory drugs
       The synthesis of ester containing amide derivatives through carboxylation reaction can inhibit bacterial cell wall synthesis or interfere with the release of inflammatory factors. These derivatives can be used to prepare broad-spectrum antibiotics (targeting Gram positive and Gram negative bacteria) and nonsteroidal anti-inflammatory drugs, suitable for treating skin infections, respiratory inflammation and other diseases, and have much lower gastrointestinal irritation than traditional anti-inflammatory drugs. They have stable demand in the high-end pharmaceutical market overseas. ​
    2. Raw materials for central nervous system drug synthesis
        Through ester hydrolysis and carboxyl cyclization reaction, piperidine and pyrrolidine central nervous system drug intermediates can be synthesized. After further modification, they can act on neurotransmitter receptors (such as dopamine receptors and 5-hydroxytryptamine receptors) for the development of anti anxiety and antidepressant drugs. The half-life of drug metabolism is moderate (4-6 hours), with minimal side effects, making it an important direction for pharmaceutical research and development. ​
    3. Intermediate of anti-tumor drugs
        Through the synergistic reaction of bifunctional groups and the introduction of targeted groups (such as folate receptor targeted groups), anti-tumor drug precursors can be synthesized. These precursor drugs can accurately act on tumor cells, inhibit tumor cell proliferation, reduce damage to normal cells, and are suitable for auxiliary treatment of lung cancer, breast cancer and other cancers, in line with the trend of "precision treatment" of overseas anti-tumor drug research and development. ​
(2) Pesticide field
     1. Intermediate herbicides
     2. Intermediate insecticides
     3. Intermediate of fungicides
(3) Fine chemical industry field
    1. Spices and essence raw materials
    2. Polymer material modifier
        As a chain extender and crosslinking agent for polyamide (nylon) and polyurethane, flexible segments are introduced through the reaction of carboxyl groups with amino and hydroxyl groups in the resin, improving the toughness (elongation at break increased by 20% -30%), heat resistance (glass transition temperature increased by 15-25 ℃), and weather resistance of polymer materials. It is suitable for the preparation of high-end engineering plastics (such as nylon for automotive parts and polyurethane seals for electronic devices), expanding the application scenarios of materials. ​
    3. Organic synthesis reagents
     (4) In the field of coatings and adhesives
         1. Paint curing agents and additives
            As a curing agent component for water-based and powder coatings, it reacts with epoxy and hydroxyl groups in the coating resin through carboxyl groups to form a cross-linked network structure, improving the adhesion of the coating (increasing adhesion to metal and wood substrates by 30% -40%), corrosion resistance (salt spray resistance time extended to over 500 hours), and wear resistance. It is suitable for high-end coating fields such as automotive coatings and industrial anti-corrosion coatings. ​
          2. Adhesive toughening agent
             Adding it to epoxy resin adhesives and polyurethane adhesives can improve the brittleness of the adhesive, enhance the bonding strength (shear strength increased by 25% -35%) and impact resistance, while not affecting the curing speed and bonding stability of the adhesive. It is suitable for electronic component bonding (such as chip packaging), building structure bonding (such as stone and metal bonding) and other scenarios.

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