104798-53-0 2-Fluoro-5-hydroxybenzenecabonitrile
Product name: 2-Fluoro-5-hydroxybenzenecabonitrile
CAS number: 104798-53-0
Molecular formula: C7H4FNO
Molecular weight: 137.11
EINECS number:
MDL No.：MFCD11846514
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Description
Properties:
Appearance White to Off white powder
Melting point: 111-113 °
Boiling point: 268 ℃
Density: 1.34
Flash point: 116 ℃
Storage conditions: Inert atmosphere, Room Temperature
Acidity coefficient (pKa) 8.59 ± 0.18
| Downstream Application Field | Specific Products | Product Description |
|---|---|---|
| Pharmaceutical Synthesis | Pharmaceutical intermediates (e.g., anti-cancer drugs, anti-inflammatory agents, kinase inhibitors, antibacterial APIs), API precursors | 2-Fluoro-5-hydroxybenzonitrile acts as a aromatic building block in pharmaceutical synthesis. Its fluorine atom (-F), hydroxyl group (-OH), and cyano group (-CN) enable diverse reactions (e.g., nucleophilic substitution, esterification, amidation, cyclization, coupling reactions), facilitating the synthesis of bioactive molecules. It is widely used in developing kinase inhibitors (targeting tumor cell proliferation) and anti-inflammatory drugs, as the fluorine atom enhances metabolic stability and target binding affinity, the hydroxyl group enables precise structural modification, and the cyano group serves as a precursor for amide/amine derivatives to optimize API bioavailability. |
| Agrochemicals | Pesticide intermediates (e.g., fungicides, insecticides, herbicides), plant growth regulators | It serves as a precursor for synthesizing high-efficiency agrochemicals. Through chemical modifications (e.g., etherification of the hydroxyl group, hydrolysis of the cyano group, heterocyclic fusion), it can be converted into active ingredients with enhanced pesticidal activity, selectivity, and environmental biodegradability. These products effectively control plant pathogens, pests, and weeds, while some derivatives act as plant growth regulators to improve crop stress resistance. The fluorine-substituted aromatic structure enhances the compound's target site specificity and persistence in crops, reducing non-target toxicity. |
| Dyes & Pigments | Fluorinated aromatic dyes, cyanated dye intermediates, functional pigments | It is used as a raw material for synthesizing high-performance dyes and pigments, especially for products requiring light fastness and chemical stability. The fluorine atom improves the dye's resistance to UV degradation and chemical corrosion, while the cyano group contributes to color intensity and molecular rigidity. Derived dyes are applied in textiles, optical materials, and industrial coatings, providing bright, durable colors with excellent environmental stability. |
| Fine Chemicals | Functional aromatic derivatives (e.g., fluorinated phenol esters, cyanophenyl amides, heterocyclic compounds), specialty intermediates | It is a intermediate for synthesizing fine chemicals. Through reactions with alcohols, amines, and halides, it produces fluorinated phenol esters (plasticizers), cyanophenyl amides (surfactants), and heterocyclic derivatives (catalysts, corrosion inhibitors). These products leverage the compound's multi-functional group reactivity to enhance performance in industrial applications such as lubricant additives and polymer modifiers. |
| Material Science | Fluorinated polymers, electroactive materials (e.g., OLED intermediates), corrosion-resistant coatings | It serves as a monomer or modifier for synthesizing fluorinated polymers (e.g., polyesters, polyamides) with enhanced thermal stability and chemical resistance. In electroactive materials, it is used to prepare OLED intermediates, where the fluorine and cyano groups tune electronic properties (e.g., charge transport efficiency, luminescence intensity). It also modifies anti-corrosive coatings for industrial equipment, improving coating adhesion and resistance to acidic/alkaline environments. |
| Laboratory & R&D | Organic synthesis reagents, fluorinated aromatic chemistry research tools, multi-functional group reaction prototypes | High-purity grades are used in academic institutions and industrial R&D laboratories. They are employed to develop novel synthetic routes for fluorinated/cyanated aromatic compounds, study the reactivity of multi-functional aromatic scaffolds, and prepare prototype materials for pharmaceutical and material science research. The compound's unique combination of -F, -OH, and -CN groups makes it a valuable tool for exploring structure-property relationships in organic chemistry. |
Synonyms:
104798-53-0
2-Fluoro-5-hydroxybenzonitrile
3-Cyano-4-fluorophenol
2-fluoro-5-hydroxy-benzonitrile
Benzonitrile, 2-fluoro-5-hydroxy-
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