CAS 42464-96-0 | 5-Amino-1-methylquinolin-1-ium Iodide

Specification:

Appearance	Brown to reddish brown powder
Purity (HPLC)	NLT 99%

 

Application:

     5-Amino-1-methylquinolin-1-ium iodide is a selective, substrate-competitive inhibitor of nicotinamide N-methyltransferase (NNMT) (IC₅₀ = 1.2 μM), with primary applications in biomedical research, metabolic disease studies, and anti-aging research.

1 Metabolic Disorder Research 

Obesity & Adipogenesis: Inhibits 3T3-L1 adipocyte differentiationand reduces lipogenesis; lowers 1-methylnicotinamide (1-MNA) levels in fat cells (EC₅₀ = 2.3 μM).

Insulin Resistance & Diabetes: Improves insulin sensitivity and glucose homeostasis by enhancing NAD⁺ salvage and mitochondrial function.

Hepatic Steatosis: Reduces liver fat accumulation and white adipose tissue mass in preclinical models.

2 Muscle & Aging Biology

Sarcopenia Treatment: Activates senescent muscle stem cells (muSCs), boosts proliferation/fusion, and enhances regenerative capacity in aged mice.

Muscle Injury Repair: Accelerates recovery post-injury with no systemic toxicity.

Lean Mass Preservation: Increases lean body mass-to-weight ratio in metabolic disease models.

3 Cellular & Epigenetic Research

NAD⁺ Metabolism: Shifts cellular "methyl economy," elevates NAD⁺ and SAM (S-adenosylmethionine) pools.

Epigenetics: Modulates DNA/histone methylation via SAM availability.

Mitochondrial Function: Enhances energy production and oxidative metabolism.

2.4 Oncology Research

Cancer Metastasis: Suppresses intraperitoneal ovarian cancer metastasis in murine models.

Tumor Metabolism: Targets NNMT-overexpressing cancer cells (e.g., liver, colon, ovarian).

 

 

Synonyms:

NNMTi
5-amino-1MQ
5-Amino-1-methylquinolinium
5-Amino-1methylquinolinium iodide
5-Amino-1-methylquinolin-1-ium iodide
 

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