CAS 1451199-98-6 | Sulanemadlin
Name: ALRN6924
CAS number: 1451199-98-6
Molecular formula: C95H140N20O23
Molecular weight: 1930.28
EINECS number:
MDL No.：
Sulanemadlin (ALRN-6924) (CAS 1451199-98-6)
Product Overview
Sulanemadlin (ALRN-6924) is a synthetic stapled peptide designed as a dual inhibitor of MDM2 and MDMX proteins. Engineered with enhanced alpha-helical stability and cell permeability, this high-purity biochemical reference compound is widely investigated for reactivating wild-type p53 tumor suppressor pathways in preclinical and oncology research.
Applications
- Oncology & Cancer Research: Evaluated in laboratory models for restored p53 activity, inducing apoptosis in TP53 wild-type leukemia, lymphoma, and solid tumor cell lines.
- Chemoprotection Studies: Investigated for transient cell-cycle arrest in normal healthy cells to protect bone marrow cells during chemotherapy routines.
- Peptide Engineering & Binding Kinetics: Utilized as a reference staple peptide standard to analyze protein-protein interaction dynamics and intracellular stability.
- Combinatorial Drug Discovery: Applied in preclinical target screening alongside targeted targeted therapies and DNA-damaging agents.
Storage & Handling
- Keep container tightly sealed under nitrogen or inert gas environment.
- Recommended storage temperature: -20°C (desiccated) for optimal peptide integrity.
- Avoid repeated freeze-thaw cycles and protect thoroughly from ambient moisture and light.
Synonyms & Identifiers
Sulanemadlin | ALRN-6924 | ALRN 6924 | CAS 1451199-98-6 | MDM2/MDMX inhibitor ALRN-6924
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