![CAS 1001346-47-9 | Spiro[cyclopropane-1,7′-[7H]pyrimido[4,5-b][1,4]diazepin]-6′(5′H)-one, 2′-chloro-9′-cyclopentyl-8′,9′-dihydro-](/uploads/41320/cas-1001346-47-9-c4c68.jpg)
CAS 1001346-47-9 | Spiro[cyclopropane-1,7′-[7H]pyrimido[4,5-b][1,4]diazepin]-6′(5′H)-one, 2′-chloro-9′-cyclopentyl-8′,9′-dihydro-
Route of Synthesis: Synonyms: 2-chloro-9-cyclopentyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-7,1'-cyclopropan-6-one 2'-chloro-9'-cyclopentyl-8',9'-dihydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepin]-6'(5'H)-one 1001346-47-9...
| Item | Details |
|---|---|
| Structural Formula | Spiro[cyclopropane-1,7'-pyrimido[4,5-b][1,4]diazepine] core with 2'-Cl, 9'-cyclopentyl, 8',9'-dihydro, 6'(5'H)-one |
| Melting Point | 200–220°C |
| Solubility | Soluble in DMSO, DMF, THF; slightly soluble in ethanol; insoluble in water |
| Purity | Typically 95% or higher (research grade); 98%+ for drug discovery |
| Properties | Spirocyclic framework for conformational rigidity; chloro-substituted for target binding; lactam group for H-bonding; stable under neutral conditions; degrades under strong acid/base |
| Market Applications |
1. Pharmaceutical R&D: compound/intermediate for kinase inhibitors, CNS agents, and anti-infectives; spirocyclic motif enhances target selectivity and ADMET properties. 2. Chemical Biology: Tool for studying enzyme-substrate interactions and signal transduction pathways. 3. Agrochemical Research: Precursor for novel spirocyclic pesticides with improved bioactivity and environmental safety. |
| Safety & Handling | Irritating to skin/eyes; harmful if swallowed/inhaled; store at 2–8°C in airtight container; use PPE (gloves, goggles, lab coat) |
Route of Synthesis:
Synonyms:
2-chloro-9-cyclopentyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-7,1'-cyclopropan-6-one
2'-chloro-9'-cyclopentyl-8',9'-dihydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepin]-6'(5'H)-one
1001346-47-9
Spiro[cyclopropane-1,7′-[7H]pyrimido[4,5-b][1,4]diazepin]-6′(5′H)-one, 2′-chloro-9′-cyclopentyl-8′,9′-dihydro-
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