93634-87-8 T-butyldicyclohexylphosphine

1. Catalysis (Organometallic & Organic Synthesis)

2. Pharmaceutical Intermediate Synthesis3. Fine Chemicals Production

1. Catalysis Field- Ligand precursor for Pd-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Stille, Buchwald-Hartwig amination)- Component of catalyst systems for olefin hydrogenation and isomerization- Ligand for Ni-catalyzed C-C bond formation reactions

2. Pharmaceutical Synthesis- ligand in catalytic systems for synthesizing antitumor drug intermediates (e.g., arylamine derivatives of targeted cancer drugs)- Catalyst ligand for preparing antibiotic intermediates (modification of β-lactam rings)- Enables efficient synthesis of chiral pharmaceutical building blocks

3. Fine Chemicals Production- Ligand for catalytic synthesis of specialty fragrances and flavors- Used in the preparation of functional organic materials (e.g., organic semiconductors)

1. Cross-coupling Reactions- Molar ratio of ligand (T-butyldicyclohexylphosphine) to metal catalyst (Pd/Ni): 1.0–2.0:1 (optimizes catalyst activity and stability)- Relative dosage to substrate: 1–5 mol% (varies by reaction type and substrate reactivity)

2. Pharmaceutical Intermediate Synthesis- Batch usage: 0.5–3 kg per ton of final pharmaceutical intermediate (depending on synthetic route and yield)

3. Fine Chemicals Preparation- Ligand dosage: 0.3–2 mol% relative to main reactant (for high-selectivity reactions)