CAS 119-62-0 | 2-Amino-1-(4-nitrophenyl)-1,3-propanediol

Properties
Melting point:163-165 °C
Boiling point:451.9±45.0 °C
Density 1.410±0.06 g/cm3

 

Market Applications

1. Pharmaceutical Industry 

    Intermediate for Chloramphenicol:  intermediate in the industrial synthesis of chloramphenicol (CAS 56-75-7), a broad-spectrum antibiotic used to treat bacterial infections.

    Synthetic Precursor: Used to prepare chiral derivatives and analogs of chloramphenicol, such as azidamphenicol and chloramphenicol palmitate, for improved pharmacokinetics or targeted therapy.

    Research & Development:  medicinal chemistry labs--synthesizing novel antimicrobial agents and studying structure-activity relationships (SAR) of nitroaryl antibiotics.

2. Organic Synthesis & Chemical Manufacturing

Chiral Building Block: Utilized as a starting material for constructing complex chiral molecules due to its two stereocenters.

Reductive Amination & Functionalization: The nitro group can be reduced to an amino group, enabling further derivatization for dyes, polymers, and specialty chemicals.

 

 

Pharmaceutical Derivatives

Chloramphenicol (CAS 56-75-7)

Chloramphenicol Palmitate (CAS 530-43-8)

Azidamphenicol (CAS 13838-08-9)

Chloramphenicol Stearate (CAS 16255-48-4)

Synthetic Intermediates

(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol (CAS 716-61-0)

N-Substituted Derivatives: e.g., N,N-dimethyl-2-amino-1-(4-nitrophenyl)-1,3-propanediol, used in further synthetic pathways.

Esterified Derivatives: e.g., 1,3-diacetoxy derivatives, serving as protected intermediates in multi-step synthesis.

 

 

Synonyms:

(S(R*,R*))-2-Amino-1-(p-nitrophenyl)propane-1,3-diol

119-62-0

2-Amino-1-(4-nitrophenyl)propane-1,3-diol

2-Amino-1-(4-nitrophenyl)-1,3-propanediol

1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-

1-(p-Nitrophenyl)-2-amino-1,3-propanediol

3689-55-2

dextramine

trans-2-Amino-1-(4-nitrophenyl)propane-1,3-diol

1-(4'-Nitrophenyl)-2-aminopropane-1,3-diol

D-(-)-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol

 

 

 

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