1188-21-2 | Levacetylleucine

Properties

Appearance White Crystalline Powder
Melting point:187-190 °C(lit.)
Boiling point:303.86°C
Density 1.1599 
refractive index -22 ° (C=5, EtOH)
 

Application:

    Levacetylleucine is mainly used to alleviate neuronal death and neuroinflammation. Research has shown that Levacetylleucine can alleviate neuronal death and neuroinflammation in mouse cortical tissue, while improving lysosomal and metabolic dysfunction
1. In addition, it can improve the compensation of posture symptoms after unilateral chemical labyrinthine resection (UL) in rats, demonstrating its potential in the prevention of neurodegenerative diseases.

application and corresponding dosage are shown in the following English table.

Category	Details
Application	1. Niemann-Pick Disease Type C (NPC): Approved by the FDA in 2024 for treating neurological symptoms (ataxia, dystonia, vertical supranuclear gaze palsy) . 2. Cerebellar Ataxia: Used to improve gait, coordination, and motor function; Phase 3 trials ongoing for ataxia telangiectasia and other forms. 3. Vestibular Dysfunction: Relieves acute vertigo and aids vestibular compensation post-unilateral labyrinthectomy, widely used in Europe for decades. 4. Neuroprotective Research: Investigated for traumatic brain injury, lysosomal storage diseases, and neurodegenerative disorders (e.g., Parkinson's) for its anti-inflammatory and metabolic-stabilizing effects. 5. Peptide Synthesis: Serves as a chiral building block for peptide/API synthesis (e.g., Enfuvirtide) to enhance solubility and stability. 6. Cosmetics (Racemic DL-form mainly): Used as a skin conditioner/moisturizer to reduce TEWL and improve texture (L-form has limited use here).
Packaging	Bulk: 25kg, 50kg fiber drums (for pharmaceutical synthesis)

 

 

Synonyms:

N-Acetyl-L-leucine

1188-21-2

acetyl-L-leucine

Ac-Leu-OH

(S)-2-Acetamido-4-methylpentanoic acid

N-acetyl-leucine

Levacetylleucine

(S)-2-Acetylamino-4-methyl-pentanoic acid

n-acetyl-L-leucin

(2S)-2-acetamido-4-methyl-pentanoic acid

(2S)-2-(acetylamino)-4-methylpentanoic acid

acetyl-leucine

 

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